Pharmacology - Frequently asked questions on anti-inflammatory drugs
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In general, you need to remember that
1. These are corticosteroids or glucocorticoids and that they suppress the immune system in addition to their anti-inflammatory activity. Thus latent infections such as tuberculosis may go systemic or opportunistic infections such as Candidiasis may become more of a problem
2. Side effect profile: gastric ulcers, immunosuppression, acute adrenal insufficiency, osteoporosis, hyperglycemia, redistribution of body fat
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Question 1 of 5
1. Question
Which of the following statements is NOT true regarding the adrenal corticosteroids?
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Question 2 of 5
2. Question
Which of the following conditions contraindicate use of corticosteroids in a dental patient?
a. AIDS
b. Candidiasis
c. Tuberculosis
d. Peptic ulcersCorrect(v) Answer is (e)- Corticosteroids are antiinflammatory drugs used topically, orally and parenterally. However, they suppress the immune system of the body. They have been known to cause peptic ulcers, as well as mask the symptoms of an ulcer, and perforation and hemorrhage may result. Thus “d” has to be in the answer, eliminating (a). Because they are immunosuppressive, they would obvious make an AIDS patient, who already has a compromised immune system, worse. Similarly, latent tuberculosis could also be reactivated. Thus # 3 and (d) can be eliminated. Use of corticosteroids in inhalers for asthma, while advantageous in reducing the side effects resulting from systemic administration, has led to an increase in problems with Candidiasis, so “b” has to be in the answer. (e) is the only answer that meets all these requirements.
Incorrect(v) Answer is (e)- Corticosteroids are antiinflammatory drugs used topically, orally and parenterally. However, they suppress the immune system of the body. They have been known to cause peptic ulcers, as well as mask the symptoms of an ulcer, and perforation and hemorrhage may result. Thus “d” has to be in the answer, eliminating (a). Because they are immunosuppressive, they would obvious make an AIDS patient, who already has a compromised immune system, worse. Similarly, latent tuberculosis could also be reactivated. Thus # 3 and (d) can be eliminated. Use of corticosteroids in inhalers for asthma, while advantageous in reducing the side effects resulting from systemic administration, has led to an increase in problems with Candidiasis, so “b” has to be in the answer. (e) is the only answer that meets all these requirements.
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Question 3 of 5
3. Question
Which of the following does NOT result from prolonged treatment with steroids?
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Question 4 of 5
4. Question
Glucocorticosteroids are useful as secondary treatment of anaphylaxis because they
Correct(d) Answer is (d)- Glucocorticoids such as hydrocortisone are classed as antiinflammatories, inhibiting every step of the inflammatory process.- thus (d) is the correct answer. The other alternatives are single steps along the pathway, that are
handled by other drugs that are more selective than glucocorticoids.Incorrect(d) Answer is (d)- Glucocorticoids such as hydrocortisone are classed as antiinflammatories, inhibiting every step of the inflammatory process.- thus (d) is the correct answer. The other alternatives are single steps along the pathway, that are
handled by other drugs that are more selective than glucocorticoids.Exhibit
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Question 5 of 5
5. Question
Adrenal steroids are used successfully to treat all of the following conditions EXCEPT
Correct(a) adrenal steroids, otherwise known as corticosteroids, actually cause gastric ulcers! All the rest are therapeutic uses.
Incorrect(a) adrenal steroids, otherwise known as corticosteroids, actually cause gastric ulcers! All the rest are therapeutic uses.
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